You may use an approved make and model of calculator as specified by the GPhC. The accepted calculators are:
- Casio MX-8S-WE
- Casio MX 8B-WE / MX-8B
- Aurora HC133
- Aurora DT210
- Unless specified, give your answer to the nearest whole number.
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Question 1 of 175
1. Question
You receive a prescription for a 9-year-old patient for Augmentin Duo oral solution. The dose is ‘5ml bd for 10 days’. The reconstituted medicine has a shelf life of 7 days. The pharmacy only has the 35ml product in stock.
CorrectIncorrectHint
Single dose containers
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Question 2 of 175
2. Question
Mr B is a 45-year-old man who has cervicalgia of the neck unsuccessfully treated with pregabalin 150mg twice a day. The Practice Pharmacist wants to switch him to the lowest equivalent gabapentin dose as an alternative.
CorrectIncorrectHint
capsules
-
Question 3 of 175
3. Question
Mrs C has CKD stage 3 and her recent biochemistry result is given below:
Sodium 139 Potassium 5.1 Bicarbonate 17.6 urea 10.3 Creatinine 148 eGFR 30 Due to her low bicarbonate levels the Renal Consultant wants to prescribe sodium bicarbonate 500mg capsules three times a day but is unsure as to how many mmol of bicarbonate that would be.
The atomic mass of sodium bicarbonate is 84.
Round your answer to the nearest whole number.
CorrectIncorrect -
Question 4 of 175
4. Question
A 15-year-old boy suffered a severe flare up of his Crohn’s. The Consultant
Endocrinologist prescribes a course of prednisolone as follows:
Prednisolone 20mg daily for one week
Prednisolone 10mg daily for one week
Prednisolone 5mg daily thereafter until review in 2 months
The boy refuses to take tablets so the Consultant has prescribed the 1mg/1ml oral
solution which is available in 5ml single-dose containers.CorrectIncorrect -
Question 5 of 175
5. Question
The District Nurse prepares 1 tablet of Permitabs® (potassium permanganate 400mg) for a patient to treat a suppurating wound on the right foot. The nurse needs to dissolve the tablet in 2.5 litres of water.
CorrectIncorrectHint
% w/v
-
Question 6 of 175
6. Question
An 18-months-old infant has underdeveloped renal function due to being born prematurely. The infant is being managed by the renal clinic at the local hospital. Currently the infant is suffering regurgitation for which the Renal Consultant would like to prescribe Gaviscon Infant sachets at the max dose but is worried about the sodium content. The Consultant does not want the infant to have more than 1g of salt per day (equivalent to 0.4g of sodium). The child weighs 5.2kg.
CorrectIncorrect -
Question 7 of 175
7. Question
Mrs Y presents with the following prescription:
CorrectIncorrect -
Question 8 of 175
8. Question
VoChem Pharmaceuticals receives a prescription for a mouthwash as follows:
Sodium Fluoride 0.02 mol/L dental rinse x600ml
The molecular weight of sodium fluoride is 42.
Round your answer to one decimal place.
CorrectIncorrect -
Question 9 of 175
9. Question
A 11-year-old child with Crohn’s disease has been prescribed ranitidine by the Paediatrician to treat active gastric ulceration. The child weighs 43kg. The Paediatrician prescribes the maximum per dose. The child wants the liquid preparation.
CorrectIncorrect -
Question 10 of 175
10. Question
Mrs T has advanced breast cancer. First line chemotherapy has failed. The oncologist now wants to try idarubicin at a dose of 45mg / m2 for one dose, with treatment repeated every 3-4 weeks. Mrs T weighs 95kg and is 1.55m tall. Idarubicin in available as Zavedos 5mg capsules.
CorrectIncorrect -
Question 11 of 175
11. Question
A 4-year-old child has been prescribed furosemide 0.5mg/kg twice a day. An oral solution containing 4 mg/mL is available in the pharmacy. Your hospital policy directs you to dilute 5ml of the solution to 20ml with water.The child weighs 12.5kg.
Round your answer to one decimal point.
CorrectIncorrect -
Question 12 of 175
12. Question
A 16-year-old boy with chronic renal failure is commencing treatment with epoetin alfa. His weight is 59kg.
CorrectIncorrect -
Question 13 of 175
13. Question
Mrs B presents with a prescription for warfarin tablets:
The pharmacist wants to dispense 3mg and 1mg tablets.
CorrectIncorrect -
Question 14 of 175
14. Question
200 ml is removed from a bag containing 500 mL of glucose 10% and replaced with 200 ml of glucose 20%.
CorrectIncorrect -
Question 15 of 175
15. Question
Mr Z presents a private prescription at your pharmacy.
The pharmacy’s private prescription charge = cost + 50% + VAT + £5 dispensing fee.
CorrectIncorrect -
Question 16 of 175
16. Question
EXTRACT PRIVATE RX + BNF TABLE suitable quantities of corticosteroid preparations
Mr Z presents a private prescription at your pharmacy.
The pharmacy’s private prescription charge = cost + 50% + VAT + £5 dispensing fee.Assume the quantities required are the minimum suitable quantities for the area and
the pack sizes available to you are:
Modrasone 0.05% cream 50g/£2.68
Hydrocortisone 1% cream 15g/£0.83
Hydrocortisone 0.5% cream 15g/0.99
Round your answer to two decimal places.-
Strength | Cost difference per tablet
mg | £
mg | £
mg | £
mg | £
mg | £
CorrectIncorrect -
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Question 17 of 175
17. Question
The General Practice Pharmacist has been directed by the CCG to switch patients on generic quetiapine to Zaluron XL as a cost saving measure to achieve the year end CCG drug expenditure targets. The cost price of the drugs is given below:
Strength Zaluron XL cost (tablets/£) Quetiapine modified release generic Drug Tariff remuneration (tablets/£) 50mg 60/27.96 60/67.66 150mg 60/46.96 60/113.10 200mg 60/46.96 60/113.10 300mg 60/70.71 60/170.00 400mg 60/93.98 60/226.20 The number of patients on this medicine and the dose they are taking is given in the table below:
Strength Zaluron XL Quetiapine modified release No. of patients Dose direction No. of patients Dose direction 50mg 2 bd 0 150mg 1 od 3 od 200mg 0 1 bd 300mg 0 2 od 400mg 0 1 od This year has 365 days. Use two decimal places for all your working out and answer.
CorrectIncorrect -
Question 18 of 175
18. Question
A patient is prescribed 1000ml of saline solution for infusion over five hours. The drop factor of the infusion set is calibrated at 20 drops/ml.
Round your answer to the nearest whole number.
CorrectIncorrect -
Question 19 of 175
19. Question
Ms P’s mother brings the discharge prescription to the hospital pharmacy for dispensing.
CorrectIncorrect -
Question 20 of 175
20. Question
The Aseptic Services Technician receives an order for 1L of 25% dextrose infusion. She has available 30% dextrose solution for infusion and a 20% dextrose solution for infusion.
CorrectIncorrect -
Question 21 of 175
21. Question
Mr B has pulmonary fibrosis and using oxygen at home delivered via a B10P oxygen cylinder which has a capacity of 2122 litres. Mr B uses a micro flowmeter which delivers oxygen at a flow rate of 0.02 litres per minute. Mr B usually uses the oxygen for approximately 16 hours per day.
Give your answer as a whole number.
CorrectIncorrect -
Question 22 of 175
22. Question
Mrs F has been taking Sevredol (morphine sulfate) 30mg every 4 hours and she had to be given it five times yesterday. The Palliative Care Nurse would like Mrs F to be transferred to parenteral diamorphine.
CorrectIncorrect -
Question 23 of 175
23. Question
You need to produce a copper sulphate (CuSO4) (anhydrous) solution containing 500ppm of copper sulphate anhydrous.
Molecular weight of CuSO4 = 159.609g/mol
Molecular weight of CuSO4.5H2O = 249.685g/mol
The crystals are 98.5% pure.
Round you answer to one decimal place.
CorrectIncorrect -
Question 24 of 175
24. Question
Mr G is prescribed morphine sulphate 120 mg to be given over 24 hours using a syringe driver. The morphine sulphate solution that is used contains 10 mg/ ml.
Round your answer to one decimal place.
CorrectIncorrect -
Question 25 of 175
25. Question
Mrs G is 65-years-old and has come in to see the Diabetes Nurse for a diabetes review. Her HbA1c is high and the nurse wants to commence additional treatment with alogliptin. Her annual check-up at her surgery included a full biochemistry blood check; her serum creatinine was found to be 105 umol/L. Mrs G weighs 58kg and is five feet 6 inches tall.
Estimated CrCl (ml/min) = (140 – age) x weight x constant
Serum creatinine
Where:
Age in years, Weight in kg, Constant = 1.23 for men or 1.04 for women
IBW Female (kg) = 45.5 + (2.3 x number of inches above five feet in height)
CorrectIncorrect -
Question 26 of 175
26. Question
A 5-year-old weighing 20kg is prescribed ceftriaxone at a dose of 50mg/kg once daily. Ceftriaxone is available as a 1g powder for solution for injection. It is to be given as an intravenous infusion in 50ml sodium chloride 0.9% infusion bag. The 1g vial has a displacement value of 0.8ml/g. The nurse reconstitutes one vial with 10ml Water for Injection PhEur and injects all the resulting solution into the 50ml infusion bag. The infusion is to be given over 30 minutes.
Round your answer to the nearest whole number.
CorrectIncorrect -
Question 27 of 175
27. Question
The table below gives details of a prospective study comparing the incidence of dyskinesia after treatment with ropinirole and levodopa in patients with early Parkinson’s Disease.
Presence of dyskinesia Yes No Ropinirole 17 162 Levodopa 23 66 Totals 40 228 Round your answer to the nearest whole number.
NNT = 1/ARR
ARR = control event rate – experimental event rate
CorrectIncorrect -
Question 28 of 175
28. Question
Baby G has been admitted to hospital with uncomplicated community acquired pneumonia. He needs an amoxicillin infusion at a dose of 50mg/kg daily in divided doses. Baby G weighs 7.5kg. One infusion is to be given over 30 minutes in a 50ml normal saline 0.9% mini-bag. The antibiotic is to be administered at a frequency of three times a day. The total content of the reconstituted vial is added to the mini-bag.
Round your answer to the nearest whole number.
CorrectIncorrect -
Question 29 of 175
29. Question
The CCG has put aside £25000 to spend on introducing a novel anticoagulant drug that has more advantages than warfarin and does not need to have patients’ INR monitored. However, there are currently three novel anticoagulants available.
The Chief Pharmacist consults the following table:
Intervention QALY gained Net cost Drug A 50 £1000 Drug B 3 £300 Drug C 40 £1200 Average cost effectiveness = net cost/net health benefit
CorrectIncorrect -
Question 30 of 175
30. Question
The CCG has £50,000 to spend on one new intervention to treat peripheral vascular disease. There are currently two different options available. Intervention X is the current CCG intervention.
The Chief Pharmacist considers the following table:
Intervention QALY gained Net cost X 20 £500 Y 30 £2000 Z 25 £1000 Incremental Cost Effectiveness Ratio (ICER) = incremental costs / incremental health gain
CorrectIncorrect -
Question 31 of 175
31. Question
Mr C is beginning treatment with aminophylline for severe acute exacerbation of COPD. He has had a loading dose and now needs a maintenance dose of 500mcg/kg/hour. His weight is 80kg.
CorrectIncorrect -
Question 32 of 175
32. Question
Mr V, DOB 21/2/1970, needs a gentamicin infusion over 60minutes to treat an intra-abdominal infection. He weighs 115kg and is 1.8m tall. To ascertain Mr V’s dosing the ward pharmacist first needs to calculate Mr V’s renal function. His serum creatinine is 84umol/L.
Round your answer to the nearest whole number.
Estimated CrCl (ml/min) = (140 – age) x weight x constant
Serum creatinine
Where: Age in years; Weight in kg; Constant = 1.23 for men and 1.04 for women
CorrectIncorrect -
Question 33 of 175
33. Question
Mrs P, 69-years-old, has developed dysphagia and needs liquid medicines. She is currently taking ferrous sulphate 200mg (65mg elemental iron) twice a day. The GP wants to prescribe Sytron elixir.
Sytron contains sodium feredetate 38mg/ml which contains 27.5mg elemental iron per 5ml.
Give your answer to the nearest 100ml.
CorrectIncorrect -
Question 34 of 175
34. Question
A patient is prescribed co-amoxiclav 1000/200mg three times a day IV for community acquired pneumonia. The nurse on the ward reconstitutes Augmentin 1000/200mg powder for solution for injection/infusion with 20ml Water for Injection Ph.Eur. The nurse administers 20ml of the resultant solution as a slow intravenous injection over 4 minutes.
Round your answer to one decimal place.
CorrectIncorrect -
Question 35 of 175
35. Question
A 9-year-old child is being treated for adrenal hypoplasia and requires replacement glucocorticoid therapy. He is prescribed hydrocortisone at a dose of 8mg/m2 daily in three divided doses with the morning dose higher than the subsequent two doses at lunchtime and teatime. The child weighs 23kg and is 1.2m tall. A special order can be made to obtain hydrocortisone solution 5mg/5ml.
Round your answer to one decimal point.
CorrectIncorrect -
Question 36 of 175
36. Question
Best Health Products is a Specials manufacturer. They receive an order for 9x500g of coconut cream preparation for eczema which contains the following ingredients:
Propylene Glycol PhEur 15%
Fractionated Coconut Oil PhEur 15%
Sodium Hydroxide PhEur 0.01%
Purified Water PhEur to 100%.
Round your answer to three decimal places.
CorrectIncorrect -
Question 37 of 175
37. Question
A 5-year-old child weighing 10kg is travelling to Angola with his family for three weeks. He requires anti-malaria prophylaxis. Prophylaxis is to start two weeks before going and to continue for four weeks after returning. The parents do not want to give the child a daily dose.
CorrectIncorrect -
Question 38 of 175
38. Question
Mrs S is a 70-year-old woman with atrial fibrillation who needs to commence digoxin therapy. She weighs 65kg. The target serum concentration is 1.25mcg/L. The loading dose is to be given in three divided doses. She has an oesophageal stricture and so prefers liquid medicines. Lanoxin comes 50mcg/ml oral solution.
VD = 7L/Kg
Salt factor = 1
Oral bioavailability = 70%
Loading Dose = VD x CP
S x F
Round your answer to one decimal place.
CorrectIncorrect -
Question 39 of 175
39. Question
The ward doctor prescribes vancomycin for a 57-year-old woman as an IV infusion at a dose of 1.5g every 12 hours and a concentration of 50mg/ml. Vancomycin comes as a 500mg vial for reconstitution and has a displacement value of 0.3ml per vial.
CorrectIncorrect -
Question 40 of 175
40. Question
A patient in intensive care requires an infusion of 500ml of 10% glucose solution. The aseptic pharmacy unit have 50% and 5% bags available.
Round your answer to the nearest whole number.
CorrectIncorrect -
Question 41 of 175
41. Question
An experimental drug in phase 1 trials, when given IV, has a plasma concentration of 78mcg/L immediately after administration. The next dose can only be given when the plasma concentration is less than 10mcg/L to reduce the risk of toxicity. The half-life of the drug is 5.5 hours.
CorrectIncorrect -
Question 42 of 175
42. Question
CorrectIncorrect -
Question 43 of 175
43. Question
Mrs X is to be started on vigabatrin at a dose of 1g daily for 1 week. The dose is to be increased at weekly intervals in steps of 500mg until a dose of 3g daily is reached.
CorrectIncorrect -
Question 44 of 175
44. Question
CorrectIncorrect -
Question 45 of 175
45. Question
A patient weighing 80 kg is prescribed drug A to maintain sedation during surgery. The IV infusion is to be delivered at a dose and rate of 1.5 mg/kg/hour.
Drug A is available to the Anaesthetist as a 50 mL bottle of 1% injection and he will dilute this to 4 mg/mL using glucose 5% prior to administration.
CorrectIncorrect -
Question 46 of 175
46. Question
Mr B, a 69 year old man has been admitted to the Coronary Care Unit with acute coronary syndrome. The consultant cardiologist has requested that a glyceryl trinitrate infusion be started at 15microgram per minute via a syringe pump. The unit currently stocks 10ml Nitrocine® ampoules and 100ml glass syringes.
CorrectIncorrect -
Question 47 of 175
47. Question
For the following question one or more of the responses are correct. Decide which of the responses is/are correct.
You receive a prescription for a 7 year old child suffering from iron deficiency anaemia. The prescription says;
‘Take 1 Ferrous Gluconate tablet twice daily for 4 weeks.’
CorrectIncorrect -
Question 48 of 175
48. Question
When 5mL of a concentrated solution of potassium permanganate is diluted with water to 500mL, a 1 in 10,000 solution is produced.
CorrectIncorrect -
Question 49 of 175
49. Question
Mrs B has been taking regular daily doses of 250 microgram of digoxin elixir for treatment of atrial fibrillation. She is now NIL by MOUTH and the doctor wants you to recommend an equivalent daily IV dose of digoxin.
CorrectIncorrect -
Question 50 of 175
50. Question
A nurse has set an infusion pump used to administer dopamine to a patient, at an initial rate of 3mL/hr which was based on a dose of 3microgram/kg/minute.
CorrectIncorrect -
Question 51 of 175
51. Question
A cream contains urea and ceramide in a ratio of 50:1.
CorrectIncorrect -
Question 52 of 175
52. Question
1 Litre infusion fluid contains 95mmol chloride ions
Sodium Chloride 0.18 % and Glucose 4% Intravenous Infusion
Ringer’s Solution
Sodium Lactate Intravenous Infusion, Compound
CorrectIncorrect -
Question 53 of 175
53. Question
Magnesium Trisilicate Mixture BP contains 5% each of magnesium trisilicate, light magnesium carbonate and sodium bicarbonate in a suitable peppermint flavoured vehicle.
CorrectIncorrect -
Question 54 of 175
54. Question
Agatha, who weighs 60 kg, needs to be given a phosphate infusion at a 400 micromol/kg rate over 10 hours for hypophosphataemia. This is to be given as a phosphate intravenous infusion
CorrectIncorrect -
Question 55 of 175
55. Question
Acetylcysteine is given for paracetamol poisoning in a total dose that is divided into three consecutive infusions over a total of 21 hours.
Which of the following volumes of acetylcysteine concentrate for intravenous infusion 200mg/mL is/are correct for the preparation of the following?
- Total of 66 mL for the first and second infusions combined for a patient weighing 65kg
- Total of 72mL for the second and third infusions combined for a patient weighing 92kg
- Total of 114mL for all infusions combined for a patient weighing 76kg
CorrectIncorrect -
Question 56 of 175
56. Question
A woman weighing 62kg is administered norepinephrine base 20mg in 500mL of glucose 5% by intravenous infusion at a rate of 0.35mL/minute.
CorrectIncorrect -
Question 57 of 175
57. Question
A couple travelling to Goa for a 2 week holiday require Malaria prophylaxis.
The recommended regime starting one week before travel, throughout stay and continuing for 4 weeks after return is;
Proguanil 200mg daily plus Chloroquine 310mg base weekly.
CorrectIncorrect -
Question 58 of 175
58. Question
Ethosuximide 500mg daily in 2 divided doses for 5 days, then, increase by 250mg every 5 days to a maintenance dose of 1.5g daily in 2 divided doses.
Supply enough for 28 days treatmen
CorrectIncorrect -
Question 59 of 175
59. Question
Mr AF, who weighs 100kg, is prescribed milrinone (as lactate) by intravenous infusion at a rate of 500 nanograms/kg/min for 11 hours after surgery. Milrinone, available as Primacor® injection, will need to be diluted to the suggested concentration with sodium chloride 0.9% prior to administration.
CorrectIncorrect -
Question 60 of 175
60. Question
Co-trimoxazole is supplied to a patient as the oral suspension formulation.
CorrectIncorrect -
Question 61 of 175
61. Question
Flupentixol injection contains 100mg of flupentixol decanoate per millilitre.
(Assume the molecular weight of flupentixol is 450 and the molecular weight of flupentixol decanoate is 600)
CorrectIncorrect -
Question 62 of 175
62. Question
You are asked to prepare 500ml of potassium permanganate solution which, when diluted 1 in 10, will produce a 0.01% solution
CorrectIncorrect -
Question 63 of 175
63. Question
- 0.025 Kg of light magnesium carbonate is required to prepare 500 mL of Magnesium Trisilicate Mixture BP
- 12500 mg of sodium bicarbonate is required to prepare 250 mL of Magnesium Trisilicate Mixture BP
- If a patient takes 15 mL three times of Magnesium Trisilicate Mixture BP for ten days they will consume 270 mmol of sodium ions from this medicine
CorrectIncorrect -
Question 64 of 175
64. Question
Mrs C has been receiving 180 mg twice daily of MST Continus (morphine sulphate sustained release). Her doctor now wants to change her to morphine sulphate oral solution every 6 hours as she is finding it difficult to swallow tablets.
CorrectIncorrect -
Question 65 of 175
65. Question
CorrectIncorrect -
Question 66 of 175
66. Question
Choose of..
CorrectIncorrect -
Question 67 of 175
67. Question
Baby B is a 14 week old baby weighing 5.3kg who is prescribed oseltamivir for post-exposure prophylaxis of influenza.
CorrectIncorrect -
Question 68 of 175
68. Question
Miss T is a 34 year old lady weighing 45 kg who is diagnosed with pulmonary tuberculosis (TB). A standard unsupervised 6-month treatment of TB regimen is being followed. She is discharged from hospital on Rifater® and ethambutol. The doctor wants the pharmacy to dispense 5 days of treatment for Miss T so that she has enough medication until she is seen at the community TB clinic.
CorrectIncorrect -
Question 69 of 175
69. Question
You are required to prepare 5L of a solution containing both sodium and potassium as chlorides, in concentration of 150mmol/L of sodium and 40mmol/L potassium.
The molecular weights of sodium chloride and potassium chloride are 58.5 and 74.5 respectively.
CorrectIncorrect -
Question 70 of 175
70. Question
A man weighing 62kg is administered an intravenous infusion containing norepinephrine base 40micrograms/mL at a rate of 0.25mL/minute.
CorrectIncorrect -
Question 71 of 175
71. Question
If the dosage schedule for the following drug (X) is as follows:
Clcr 20-50ml/min 2.5mg/kg every 8 hours
Clcr 10-20ml/min 1.25mg/kg every 12 hours
Clcr <10ml/min 0.625mg/kg every 12 hours
Mrs J has come into hospital requiring a dose. Her renal function looks off and you are asked to calculate the dose for the above drug X. She weighs 50kg and is 88 years old. Her serum creatinine (S Cr ) level is 295micromoles/L.The formula for creatinine clearance is as follows:
Clcr (mL/min) = (140 – Age) x weight (kg) x constant / Scr (micromole/L)
Constant = 1.04 for women; 1.23 for men
CorrectIncorrect -
Question 72 of 175
72. Question
CorrectIncorrect -
Question 73 of 175
73. Question
A doctor wants a patient to use 150mL of a 1 in 10,000 solution of potassium permanganate as a soak 4 times a day. He wants you to dispense 2L of a solution such that when 15mL is diluted with water to make 150mL the 1 in 10,000 solution is produced
CorrectIncorrect -
Question 74 of 175
74. Question
You are doing a ward round when a Doctor on the Paediatric ward approaches you asking for advice. The doctor is treating a 22 day old neonate who weighs 3.5kilograms and is suffering from impetigo.
The doctor wishes to treat the patient with oral flucloxacillin and wants to know what the total daily dose should be
CorrectIncorrect -
Question 75 of 175
75. Question
A 10ml ampoule of potassium chloride 15% is added to 590ml of sodium chloride intravenous infusion.
0.15%
0.25%
0.30%
0.45%
0.90%
CorrectIncorrect -
Question 76 of 175
76. Question
- 20mL of 0.5% injection contains 100mg of propofol
- 100mL of 1% contains 1000mg of propofol
- 5mL of 2% injection contains 10mg of propofol
CorrectIncorrect -
Question 77 of 175
77. Question
Sodium nitroprusside is to be infused at a rate of 1 microgram/kg/minute for 5 minutes and then increased by 500nanograms/kg/minute every 5 minutes until 2 microgram/kg/minute is reached.
The patient weighs 60kg
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Question 78 of 175
78. Question
Choose of…
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Question 79 of 175
79. Question
You chose…
CorrectIncorrect -
Question 80 of 175
80. Question
Mr T has been to the dermatologist for a flare up of his eczema and brings in a prescription for 50g of hydrocortisone cream 0.4 %w/w. You decide to prepare this product extemporaneously in the dispensary using your stock of hydrocortisone 2.5% w/w.
CorrectIncorrect -
Question 81 of 175
81. Question
You are required to prepare 150g of betamethasone (as valerate) 0.025% cream using Betnovate® cream and suitable diluent cream.
- 37.5g of Betnovate® cream and 112.5g of diluent cream will be required
- Betamethasone 0.025% is a 1 in 3 dilution of Betnovate® cream
- 150g of betamethasone 0.025% contains 0.000375kg of betamethasone as valerate
CorrectIncorrect -
Question 82 of 175
82. Question
CorrectIncorrect -
Question 83 of 175
83. Question
The doctor has prescribed a 3-day course of oral azithromycin for a 1-year old child weighing 10kg
CorrectIncorrect -
Question 84 of 175
84. Question
CorrectIncorrect -
Question 85 of 175
85. Question
Molecular weight of sodium chloride is 58.5
CorrectIncorrect -
Question 86 of 175
86. Question
A child aged 3 years weighing 15kg has been prescribed oral Ranitidine 75mg/5ml for gastrooesophageal reflux disease. The dose of Ranitidine prescribed is 2.4mg/kg twice daily.
CorrectIncorrect -
Question 87 of 175
87. Question
Mr B has been taking phenytoin capsules and is stabilised on 300mg daily. Following his stroke, he has developed swallowing difficulties and the doctor has switched him to suspension.
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Question 88 of 175
88. Question
Mr Q , who has epilepsy, has been admitted to hospital and is having difficulty in swallowing his phenytoin 300mg capsule which he takes daily at night. His doctor wants to put him on an equivalent dose of suspension (30mg/5mL).
CorrectIncorrect -
Question 89 of 175
89. Question
Mrs C is to be given an emergency dose of drug D in the emergency department of your hospital. 0.75mg of drug D is to be given intravenously. The injection of drug D to be used to prepare the infusion is 250mcg/ml.
CorrectIncorrect -
Question 90 of 175
90. Question
A 12 year old boy suffering from seizures is prescribed lamotrigine as monotherapy in accordance with the recommended dosing schedule.
CorrectIncorrect -
Question 91 of 175
91. Question
A father collects a 100mL bottle of Dozic® oral liquid for his daughter who currently takes 5mg three times a day of haloperidol for schizophrenia.
CorrectIncorrect -
Question 92 of 175
92. Question
A patient is prescribed clonidine tablets as follows:
Clonidine 50micrograms 3 times daily for 2 days, then
Clonidine 100micrograms 3 times daily for 4 days, then
Clonidine 150micrograms 3 times daily for 2 days, then
Clonidine 200micrograms 3 times daily for 2 days.
Clonidine tablets are available as scored 100microgram tablets
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Question 93 of 175
93. Question
Mr SA has been receiving 20mL of Morphine Sulphate Oral Solution 10mg in 5mL every 4 hours. His palliative care nurse now wants to change him to 12 hourly MST (Morphine Sulphate) tablets.
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Question 94 of 175
94. Question
- 3.5 microgram/minute
- 7 microgram/minute
- 35 microgram/minute
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Question 95 of 175
95. Question
Simple eye ointment is used to help lubricate the eyes of patients suffering from dry eye syndrome. It contains liquid paraffin, wool fat and yellow soft paraffin.
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Question 96 of 175
96. Question
A 3 month old child weighing 6 kg has been prescribed clarithromycin suspension
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Question 97 of 175
97. Question
300 mL of a solution containing potassium chloride 0.3% w/v, 150 mL of a solution containing potassium chloride 0.15% w/v and 150 mL of a solution containing potassium chloride 15% w/v are mixed together
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Question 98 of 175
98. Question
Weeks 1-3: 50 mg daily
Week 4: 40 mg daily
Then reduce by 5 mg every 5 days until zero then stop
(You can assume this patient only uses prednisolone as 2.5 mg ec tablets)
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Question 99 of 175
99. Question
A patient being treated for Parkinson’s disease is prescribed with pergolide as follows:
0.05 mg daily for 2 days, then 150 microgram daily in 3 divided doses for 3 days then, 300 microgram daily in 3 divided doses for 3 days then, 450 microgram daily in 3 divided doses for 3 days then, 600 microgram daily in 3 divided doses for 3 days.
You can assume the patient is completely compliant with their therapy and only takes pergolide (as mesilate) as 50 microgram tablets for these 2 weeks.
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Question 100 of 175
100. Question
800g of an ointment mixture is made by adding 1 part Dovonex®ointment to 3 parts of a suitable diluent ointment.
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Question 101 of 175
101. Question
QUESTION REPLACED – A 12-year old boy weighing 30kg is prescribed the growth hormone mecasermin 40microgram/kg by subcutaneous injection twice daily for one week to be increased by 40microgram/kg increments at two weekly intervals until a dose of 120microgram twice daily is reached.
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Question 102 of 175
102. Question
An adult patient who suffered an anaphylactic reaction to a bee sting had to receive 3 x 0.5mL of epinephrine 1 in 1000 injection at 5 minute intervals.
- The patient received a total of 1.5mg of epinephrine
2.The percentage strength of epinephrine in the preparation is 0.01%
- Epinephrine is available in the preparation as 2mg/mL
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Question 103 of 175
103. Question
Mr and Mrs A are travelling to India for 2 weeks in one month’s time and require malaria prophylaxis medication. Both Mr and Mrs A are not taking any other medication and do not have any medical conditions. The community pharmacist recommends they take Proguanil and Chloroquine.
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Question 104 of 175
104. Question
You chose…
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Question 105 of 175
105. Question
Aimée currently takes ferrous fumarate 1 tablet three times a day for iron deficiency anaemia. However, her GP is informed that ferrous fumarate is currently unavailable due to a manufacturing problem. He wants to switch her to ferrous gluconate tablets.
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Question 106 of 175
106. Question
Sodium chloride M/R tablets contain 600mg of sodium chloride and are used in the prophylaxis of sodium chloride depletion.
A patient is prescribed 8 tablets daily
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Question 107 of 175
107. Question
Mrs L comes into hospital with a stroke. She was previously taking phenytoin capsules at home and now needs to be switched onto a liquid because she is having swallowing difficulties. Her stable dose at home was 300mg but there is a bioavailability difference with the liquid.
90mg of liquid is equivalent to 100mg of capsules. The liquid is available as 30mg/5ml suspension
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Question 108 of 175
108. Question
First statement: 300 mg dispersible tablets are less cost-effective than using four of the 75 mg dispersible tablets.
Second statement: 300 mg dispersible aspirin tablets are approximately 4 pence each
You chose…
Both statements are true and the second statement is a correct explanation of the first statement.
Both statements are true but the second statement in NOT a correct explanation of the first statement
The first statement is true but the second statement is false
The first statement is false but the second statement is true
Both statements are false
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Question 109 of 175
109. Question
The maximum metabolic capacity (Vm) is 7mg/kg/day,
The plasma concentration at which the rate of metabolism is half the maximum (Km) is 4mg/l
The bioavailability (F) and salt factor (S) of phenytoin are both 1.
Maintenance dose (mg) = Vm x Plasma concentration
S x F x (Km+ Plasma concentration)
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Question 110 of 175
110. Question
A 3-year old child with epilepsy is prescribed sodium valproate at a dose of 10mg/kg/day.
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Question 111 of 175
111. Question
You are a palliative care Pharmacist and are trained as a Pharmacist Prescriber. During a clinic you hold weekly in a local hospice you are reviewing the analgesia for a patient with terminal Cancer. The patient is currently taking an OxyContin® 40 mg tablet and an OxyContin® 20 mg tablet twice daily. During the appointment you and the patient agree that a rescue dose of oxycodone hydrochloride for breakthrough pain is needed to improve their pain relief. The Clinical Management Plan you have in place for this patient allows you to prescribe rescue doses of oxycodone at a dose of one sixth of their total daily oxycodone hydrochloride intake.
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Question 112 of 175
112. Question
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Question 113 of 175
113. Question
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Question 114 of 175
114. Question
QUESTION TOO HARD – Mr N is admitted to the High Dependency Unit of a hospital for the treatment of hypothyroid coma. The doctor decides to prescribe liothyronine.
Mr N responds to liothyronine injection 25µg morning and evening. It is Friday lunchtime and the nurse asks you to ensure there is enough supply of liothyronine injection up to and including Monday morning’s dose as they have none left
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Question 115 of 175
115. Question
A syringe driver contains 5 mL of diamorphine hydrochloride 10 mg/mL solution. The length of the syringe driver is 5 cm and the rate is set at 7.5 mm/hour.
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Question 116 of 175
116. Question
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Question 117 of 175
117. Question
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Question 118 of 175
118. Question
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Question 119 of 175
119. Question
A patient is given a single intravenous dose of drug A and their peak serum concentration is found to be 500mcg/ml. The elimination half-life of this drug is 240 minutes
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Question 120 of 175
120. Question
You are asked to recommend a suitable dose of oral morphine to treat breakthrough pain in a 79 year old palliative patient. The patient is currently taking MST Continus® 15mg every 12 hours.
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Question 121 of 175
121. Question
A doctor wants one of his patients to be started on a solution containing norepinephrine (as base) 40microgram/mL, infused at 0.16mL/min for 2 hours, then 0.18mL/min for 2 hours then 0.2mL/min.
- After 4 hours the patient would have received 16.3mg of norepinephrine
- The initial infusion rate should be set at 15mL/hour
- To deliver the dose of 0.2mL/min the infusion should be set at 12mL/hour
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Question 122 of 175
122. Question
Mrs C is prescribed 1g vancomycin to be given by IV infusion over 1 hour every 12 hours for 10 days to treat MRSA infection.
Each vial needs to be reconstituted and then diluted to a maximum concentration of 5mg/mL in sodium chloride 0.9%.
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Question 123 of 175
123. Question
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Question 124 of 175
124. Question
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Question 125 of 175
125. Question
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Question 126 of 175
126. Question
A patient is given a single intravenous dose of drug C and his peak serum concentration is found to be 0.45mg/mL. 24 hours later his serum concentration is found to be 56.25mg/L.
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Question 127 of 175
127. Question
Miss K is 14 years old, weighs 43 kg and has a height of 145 cm. She is prescribed mycophenolate mofetil at a dose of 300 mg/m2 twice daily. Miss K is to be prescribed this drug as CellCept® oral suspension.
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Question 128 of 175
128. Question
The patient, who cannot take tablets, is to receive a dose of 150mg daily.
Due to the stability of the product you only prepare sufficient medicine for a 1 week supply.
The formula you are going to use includes Concentrated Chloroform Water 2.5mL per 100mL suspension, but you only have available to you either Chloroform Water Single strength or Chloroform Water Double Strength.
The suspension is prepared such that the total daily dose is within 5mL of the suspension.
You can assume no excess is prepared in the manufacturing process.
- The strength of the suspension prepared is 150mg/5mL
- It would be appropriate to use 21 spironolactone 50mg tablets in manufacturing the suspension
- If you made the product using Chloroform Water Double Strength it would be appropriate to use 0.875mL
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Question 129 of 175
129. Question
A man weighing 57kg is administered dopamine hydrochloride by intravenous infusion at a rate of 2.5micrograms/kg/minute.
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Question 130 of 175
130. Question
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Question 131 of 175
131. Question
In your pharmacy you have a stock solution of drug D with a concentration of 15% w/v. Drug D is used as a mouthwash at a concentration of 0.5% w/v.
You are requested to supply 75mL of a solution of intermediate strength, such that the patient will dilute this solution 1 in 10 to get the correct concentration immediately prior to use.
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Question 132 of 175
132. Question
A patient is prescribed NuTRIflex® Lipid peri (2500mL bag). The prescribing doctor wants you to increase the sodium ion content in the bag to 103mmol.
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Question 133 of 175
133. Question
Adam, who is 54 years old, has been prescribed cimetidine by a gastroenterologist. The Doctor has contacted you, as the clinical Pharmacist on his ward, to confirm that he has prescribed an appropriate dose for Adam.
With reference to Adam’s clinical records you note that his serum creatinine is 0.15 micromol/mL, he has an ideal weight of 68kg and his height is 1.7 m. The current policy in your hospital is to use the Cockcroft and Gault formula to assess renal function.
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Question 134 of 175
134. Question
Mrs B has been taking regular daily doses of 250 microgram of digoxin elixir for treatment of atrial fibrillation. She is now NIL by MOUTH and the doctor wants you to recommend an equivalent daily IV dose of digoxin.
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Question 135 of 175
135. Question
Mr AL who is 98kg and 180cm tall has been advised by his doctor to lose weight
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Question 136 of 175
136. Question
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Question 137 of 175
137. Question
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Question 138 of 175
138. Question
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Question 139 of 175
139. Question
A nurse has set an infusion pump used to administer dopamine to a patient, at an initial rate of 3mL/hr which was based on a dose of 3microgram/kg/minute.
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Question 140 of 175
140. Question
A 52 year old woman weighing 112kg requires an intravenous loading dose of phenobarbital.
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Question 141 of 175
141. Question
Mrs W is a 78 year old lady weighing 66 kg and is diagnosed with acute myocardial infarction. Her ECG shows ST elevation therefore the doctor prescribes enoxaparin.
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Question 142 of 175
142. Question
If the dosage schedule for the following drug (X) is as follows:
Clcr 20-50ml/min 2.5mg/kg every 8 hours
Clcr 10-20ml/min 1.25mg/kg every 12 hours
Clcr <10ml/min 0.625mg/kg every 12 hours
Mrs J has come into hospital requiring a dose. Her renal function looks off and you are asked to calculate the dose for the above drug X. She weighs 50kg and is 88 years old. Her serum creatinine (S Cr ) level is 295micromoles/L.The formula for creatinine clearance is as follows:
Clcr (mL/min) = (140 – Age) x weight (kg) x constant / Scr (micromole/L)
Constant = 1.04 for women; 1.23 for men
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Question 143 of 175
143. Question
Agnes uses Curatoderm® ointment on a regular basis for the management of plaque psoriasis. She has been newly prescribed Curatoderm® lotion also for plaque psoriasis. Agnes, currently uses 0.2 mg weekly of tacalcitol (as monohydrate) through application of the ointment
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Question 144 of 175
144. Question
An adult patient who suffered an anaphylactic reaction to a bee sting had to receive 3 x 0.5mL of epinephrine 1 in 1000 injection at 5 minute intervals.
- The patient received a total of 1.5mg of epinephrine
2.The percentage strength of epinephrine in the preparation is 0.01%
- Epinephrine is available in the preparation as 2mg/mL
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Question 145 of 175
145. Question
) A patient is given a single intravenous dose of drug D and his peak serum concentration is found to be 900mcg/mL. 12 hours later his serum concentration is found to be 0.1125g/L.
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Question 146 of 175
146. Question
This drug is used as a mouthwash at a concentration of 0.2% w/v. You are requested to supply 20 mL of a solution of intermediate strength, such that the patient will dilute it 1 in 20 immediately prior to use to produce the mouthwash at the correct concentration
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Question 147 of 175
147. Question
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Question 148 of 175
148. Question
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Question 149 of 175
149. Question
A nurse has set up a dopamine infusion for a 70kg patient to run at a rate of 4ml/hr.
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Question 150 of 175
150. Question
) Mr AJ, who weighs 69kg, is prescribed aciclovir by intravenous infusion for simplex encephalitis, given over 1 hour, every eight hours. Zovirax IV© will need to be diluted with sodium chloride 0.9% prior to administration.
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Question 151 of 175
151. Question
A male patient has been prescribed oral idarubicin hydrochloride as monotherapy for acute nonlymphocytic leukaemia at the standard dose. This patient weighs 80kg and his height is 1.8m.
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Question 152 of 175
152. Question
- 37.5g of Betnovate® cream and 112.5g of diluent cream will be required
- Betamethasone 0.025% is a 1 in 3 dilution of Betnovate® cream
- 150g of betamethasone 0.025% contains 0.000375kg of betamethasone as valerate
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Question 153 of 175
153. Question
Benylin®Dry Cough syrup contains:
Dextromethorphan hydrobromide 7.5mg in 5mL
Ethanol 6 vol%
- The concentration of dextromethorphan in the syrup is 0.15%
- 90L of the cough syrup will contain 135g of Dextromethorphan
3. 50L of the syrup will contain 6000mL of ethanol
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Question 154 of 175
154. Question
You are required to extemporaneously prepare an ointment for a baby with nappy rash. You have to add an additional 25g of zinc oxide and 15g of cetostearyl alcohol to 250g of Zinc and Castor Oil Ointment BP.
- 250g of Zinc and Castor Oil Ointment BP contains 25g of white beeswax
- The concentration of zinc oxide in the newly prepared ointment will be 17.5% w/w
- The concentration of cetostearyl alcohol in the newly prepared ointment will be 8% w/w
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Question 155 of 175
155. Question
A doctor wants a patient to use 150mL of a 1 in 10,000 solution of potassium permanganate as a soak 4 times a day. He wants you to dispense 1500mL of an intermediate strength solution such that when 15mL is diluted to 150mL with water a 1 in 10,000 is produced
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Question 156 of 175
156. Question
Ann is to be prescribed an intravenous infusion of paracetamol for moderate pain after surgery. Following reference to her medical notes you ascertain that Ann is 20 years old, weighs 48kg and has neither renal nor hepatic impairment.
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Question 157 of 175
157. Question
To avoid the possibility of an incompatibility reaction, it is recommended that following a course of drug E, administration of drug F should be avoided until the plasma level of drug E has fallen to below 10mg/mL.
The half-life of drug E is 6 hours and the half-life of drug F is 4 hours.
Gregory has been prescribed drug E at a daily intravenous dose of 200mg for the past week. Drug E was stopped at 8am on 1st March and at 10am on the same day his plasma level of drug E was 60mg/mL.
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Question 158 of 175
158. Question
A dermatologist has asked you to dispense 200g of an ointment. The ointment is to be prepared by diluting betamethasone and clioquinol ointment with white soft paraffin BP in a ratio of 1 part to 3 parts respectively.
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Question 159 of 175
159. Question
You chose…
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Question 160 of 175
160. Question
You are working in the ITU and come across a patient that requires liposomal amphotericin to treat cryptococcal meningitis. You must screen the prescription and inform the nurse on how to administer this medicine. The patient weighs 60kg, your hospital formulary uses Abelcet, and the test dose has already been administered.
- It will take 2 hours to administer the daily dose
- The infusion rate is 2.5mL per min
- The dose is 300mg once daily
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Question 161 of 175
161. Question
Due to a manufacturing difficulty with Gastrocote® tablets a patient has now been prescribed Gastrocote® liquid instead. The patient previously chewed 2 of the tablets 4 times a day for acid reflux management. The prescribed dose of the Gastrocote® liquid is 10ml 4 times a day.
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Question 162 of 175
162. Question
An adult patient weighing 80kg requires intravenous teicoplanin; a loading dose and subsequent treatment for a total of seven days for a non-endocarditis infection.
Statement 1: The dose will be 400mg 12 hourly for 3 doses then 400mg OD.
Statement 2: If vials are shared between doses, the minimum number of vials required will be 10 vials of 400mg.
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Question 163 of 175
163. Question
You chose…
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Question 164 of 175
164. Question
A doctor wants a patient to use 150mL of a 1 in 10,000 solution of potassium permanganate as a soak 4 times a day. He wants you to dispense 1500mL of an intermediate strength solution such that when 15mL is diluted to 150mL with water a 1 in 10,000 is produced.
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Question 165 of 175
165. Question
Ann is to be prescribed an intravenous infusion of paracetamol for moderate pain after surgery. Following reference to her medical notes you ascertain that Ann is 20 years old, weighs 48kg and has neither renal nor hepatic impairment.
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Question 166 of 175
166. Question
A patient suffering from Parkinson’s disease has to take the following bromocriptine dosing regimen:
Week 1 – 1.25mg at night
Week 2 – 2.5mg at night
Week 3 – 2.5mg BD
Week 4 – 2.5mg TDS
Week 5 – increase dose by 2.5mg every 3 days
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Question 167 of 175
167. Question
The nurse prepares the magnesium sulphate infusion to administer to the patient via a syringe pump. The additive label reads “magnesium sulphate 5g in 25ml”.
- The concentration of magnesium sulphate in this solution is 200mg/ml
- The rate of the infusion should be set at 5ml/hr
- The infusion should last for 25 hours
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Question 168 of 175
168. Question
A patient suffering from depression is started on buspirone 5mg three times a day. The dose is to be increased by 5mg increments every 3 days until a dose of 30mg daily in three divided doses is reached.
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Question 169 of 175
169. Question
A patient requires initiation of an inotropic sympathomimetic by intravenous infusion
- 250 mL infusion bag of sodium chloride 0.9%
- 500 mL infusion bag of glucose 5%
- 1000 mL infusion bag of sodium chloride 0.9%
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Question 170 of 175
170. Question
50g of drug X will dissolve in 50mL of water to form 80mL of solution.
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Question 171 of 175
171. Question
800g of an ointment mixture is made by adding 1 part Dovonex®ointment to 3 parts of a suitable diluent ointment.
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Question 172 of 175
172. Question
1kg of an ointment mixture is made by adding 1 part Dovonex®ointment to 3 parts of a suitable ointment diluent.
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Question 173 of 175
173. Question
A patient is prescribed Plasma-Lyte® 148 (water). Prior to administration the prescribing registrar asks you to aseptically increase the potassium ion content in the 1000 mL bag to 9 mmol.
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Question 174 of 175
174. Question
400 mL of a 50 ppm solution of Victoria Blue B is to be produced. 50 mL of this solution will then be diluted to a final volume of 2 L.
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Question 175 of 175
175. Question
You receive a prescription for a 9-year-old patient for Augmentin Duo oral solution. The dose is ‘5ml bd for 10 days’. The reconstituted medicine has a shelf life of 7 days. The pharmacy only has the 35ml product in stock.
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